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NMN

NMN (Nicotinamide Mononucleotide) is a natural molecule found in the human body and in certain foods, such as broccoli, avocado, and asparagus, in tiny amounts. NMN is a precursor to NAD+, a molecule essential for the normal function of many cells in the body. Most of the positive evidence comes from animal studies; in humans, the prominent study found an improvement in muscle insulin sensitivity.

⏱️3 Reading minutes ✍️Nir Nagar 👁️892 Views

NMN (Nicotinamide Mononucleotide) is a natural molecule found in the human body and in certain foods, such as broccoli, avocado, and asparagus, in tiny amounts. NMN is a precursor to NAD+, a molecule essential for the normal function of many cells in the body.

What is known about NMN:

  • Animal studies: Studies in mice and other animals have shown that NMN may extend lifespan and improve health markers in older animals. It is important to emphasize that these are results in animals, and they have not necessarily been replicated in humans.
  • Brain function: In animal models, a potential effect on memory and learning was observed, but a randomized controlled trial in healthy older men (250 mg per day for 12 weeks) raised blood NAD+ levels but did not show significant improvement in cognitive function. Evidence in humans is still limited.
  • Metabolic health: The most prominent human study to date (Yoshino et al., Science journal, 2021) found that NMN improved muscle insulin sensitivity in postmenopausal women with prediabetes. This is a focused result, not proof of protection against heart disease, Alzheimer's, or cancer.
  • Energy production: NMN contributes to the production of NAD+, a molecule essential for energy production in cells.

Cautionary note: NMN raises NAD+ levels in the body. There is a theoretical reservation, based mainly on animal models, that raising NAD+ could fuel certain types of cancer. Therefore, it is recommended to avoid taking NAD+ precursors in the presence of active cancer, unless under the supervision of a doctor or oncologist.

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*It is always recommended to review the reviews.

Very important: The information presented on this website is not a substitute for professional medical advice.
It is important to consult with a doctor before making significant lifestyle changes or taking supplements.

ניר נגר

Nir Nagar

Nir Nagar, founder and editor of Reverse Aging and a biohacker with over 20 years of hands-on experience in longevity research, supplements, and health optimization. He researches every topic in depth before publishing, honestly grades the strength of the evidence, and links to the original studies in every article.

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