Seragon Biosciences, a research-based biopharmaceutical company, has developed a novel candidate for anti-aging intervention called SRN-901.
SRN-901 has recently undergone extensive pre-clinical research, yielding extremely impressive results.
Research results:
The study, conducted on mice, found that SRN-901:
- Increased the remaining lifespan of middle-aged mice by ⅓.
- Significant improvement in several parameters of health expectancy and metabolic markers.
- Having a positive effect on genes related to longevity, while reducing the activity of genes related to aging.
- Increase important antioxidants and reduce metabolic markers associated with poor health.
Expansion on the effects at the molecular and cellular level:
This study of SRN-901 showed one of the largest increases in life expectancy and health expectancy seen to date among the treated population. To understand how SRN-901 works at the molecular level, the researchers sequenced the genome transcriptome of over 300 mice.
This sequencing makes it possible to examine all the mRNA molecules in the cell, which represent the active genes.
The results revealed a significant increase in the expression of many genes associated with longevity, alongside a significant decrease in the expression of genes linked to aging.
In addition, metabolic analysis showed positive changes in several biomarkers indicating a younger biological age.
Significant improvement in general health:
Beyond extending life span, additional tests were conducted to evaluate SRN-901's effect on health span, which measures how long a person or animal remains in good health.
The study also examined physical and cognitive functions.
Moving fence running tests showed a marked improvement in the endurance of adult mice given SRN-901.
Their frailty scores also improved significantly, meaning their overall health improved significantly.
Furthermore, a significant decrease in the appearance of tumors was observed in the treatment group.
The following steps:
The Seragon Biosciences research team is very optimistic about the research results.
They will perform additional analyzes to reveal additional findings.
Once the supplementary analyzes are completed, the full results will be published.
Importance of research:
This research represents significant progress in the field of aging and longevity.
If SRN-901 proves effective in humans, it could change the way we approach aging and age-related diseases.
It may have a significant impact on people's health and longevity in the future.
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